P01.53. Spheroid formation and axonal severing in adult neurons during oxidative stress: role of calcium
نویسندگان
چکیده
Purpose Axonal severing is critical to the irreversible disability that occurs over the course of multiple sclerosis (MS). Reactive oxygen species (ROS) are implicated in neurodegenerative aspects of MS: axonal spheroid formation, severing, and axoplasmic Ca elevation. However, the exact role of Ca in spheroid formation remains unclear. The mechanism of action of natural anti-oxidants such as lipoic acid, which provide neuroprotection during oxidative stress in MS model, also remains unclear.
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